NMD takes two PIN domains to tango
- Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, CH-3012 Bern, Switzerland
- Corresponding author: oliver.muehlemann{at}unibe.ch
Abstract
Three new studies (Arpa et al., J Mol Biol 169734 [2026]; Kurscheidt et al., Nat Commun 17: 1934 [2026]; Modena et al., RNA, this issue [2026]) found that the PIN domains of SMG5 and SMG6, two proteins involved in nonsense-mediated mRNA decay (NMD), interact and show that the physiological endonucleolytic activity initiating the degradation of the nonsense mRNA is exerted by this composite catalytic site.
Keywords
This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
