NMD takes two PIN domains to tango
- ↵* Corresponding author; email: oliver.muehlemann{at}unibe.ch
Abstract
Three new studies (Arpa et al. 2026; Kurscheidt et al. 2026; Modena et al. 2026) found that the PIN domains of SMG5 and SMG6, two proteins involved in nonsense-mediated mRNA decay (NMD), interact and show that the physiological endonucleolytic activity initiating the degradation of the nonsense mRNA is exerted by this composite catalytic site.
Keywords
- Received March 5, 2026.
- Accepted March 6, 2026.
- Published by Cold Spring Harbor Laboratory Press for the RNA Society
This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
