Cover image

Crystal structure of protease factor Xa bound to RNA aptamer 11F7t and rivaroxaban (Protein Data Bank code: 5vof; Gunaratne R, Kumar S, Frederiksen JW, Stayrook S, Lohrmann JL, Perry K, Bompiani KM, Chabata CV, Thalji NK, Ho MD, Arepally G, Camire RM, Krishnaswamy S, Sullenger BA. 2018. Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. Nat Biotechnol 36: 606–613). The RNA aptamer backbone is displayed as an orange ribbon; bases are shown as blocks with NDB coloring: A—red, C—yellow, G—green, U—cyan; protein is shown as a silver ribbon; rivaroxaban ligand is shown in spacefill with element colors: C—white, N—blue, O—red, S—yellow, Cl—green. The image was generated using 3DNA/blocview and PyMol software. Cover image provided by the Nucleic Acid Database (ndbserver.rutgers.edu).