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On the cover

Cover Illustration: Crystal structure of Thermus thermophiles Cse3 bound to a CRISPR RNA (Protein Data Bank code: 3qrq; Gesner EM, Schellenberg MJ, Garside EL, George MM, MacMillan AM. 2011. Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat Struct Mol Biol 18: 688–692). Image details show protein—solid surface, turquoise; RNA—ribbon-plate representation, base-specific coloring, A—red, G—green, C—blue, U—magenta. The image was generated with the Accelrys Discovery Studio Visualizer. Cover image provided by the Jena Library of Biological Macromolecules—JenaLib (www.fli-leibniz.de/IMAGE.html).