TABLE 3.
Summary of Argonaute protein interactors
| Category | Organism | Argonaute | Interactors | Function | Citation |
|---|---|---|---|---|---|
| Biogenesis factors | Drosophila | AGO2 | Dicer-2, R2D2 | Facilitate siRNA biogenesis and loading | Okamura et al. 2011; Liu et al. 2003; Tomari et al. 2007; Förstemann et al. 2007 |
| C. elegans | ALG-1 | RDE-4 | Facilitate siRNA biogenesis and loading | Knittel et al. 2025 | |
| HSP chaperone/co-chaperone | Drosophila | AGO2 | HSP70, HSP90, HSP40 | Faciliate siRNA duplexes loading | Iwasaki et al. 2010; Miyoshi et al. 2010; Iwasaki et al. 2015 |
| Human | AGO2 | HSP70, HSP90, HSP40 | Faciliate siRNA and miRNA duplexes loading | Naruse et al. 2018 | |
| Arabidopsis | AGO1 | HSP70, HSP90 | Faciliate siRNA and miRNA duplexes loading | Iki et al. 2010 | |
| C. elegans | ALG-1 | DNJ-12, HSP70 | Faciliate miRNA loading | Frédérick et al. 2024 | |
| Others | C. elegans | WAGO-1, HRDE-1 | GLH-1, GLH-4 | Faciliate WAGO-22G-RNA loading | Dai et al. 2021 |
| C. elegans | NRDE-3 | ENRI-2 | May faciliate ERGO-22G-RNA loading | Lewis et al. 2020; Chen and Phillips 2025 | |
| C. elegans | HRDE-1 | HRDE-2 | Faciliate WAGO-22G-RNA loading | Chen and Phillips 2024 |
