Structural and functional characterization of the SLA′ structure at the 3′ terminus of the Zika virus negative-strand intermediate

TABLE 2.

Predicted Gibbs free energy of SLA and SLA′ in ZIKV G·U mutants

Virus Positive strand Negative strand
Structure ΔG (kcal/mol) Structure ΔG (kcal/mol)
WT SLA −21.6 SLA′ −16.1
BS (G·U) SLA −21.3 SLA′ −13.5
TSL-L (G·U) SLA −19.9 SLA′ −14.7
TSL-U (G·U) SLA −21.2 SLA′ −16.5

This Article

  1. Published in Advance May 8, 2025, doi: 10.1261/rna.080342.124 RNA 31: 1139-1153

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