RNase L produces tRNA-derived RNAs that contribute to translation inhibition

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FIGURE 2.
FIGURE 2.

RNase L cleaves various tRNA species into tDRs in A549 cells. RNase L activated by poly(I:C) transfection induces tDRs originating from various tRNA species. (A) SYBR Gold staining and (B) northern blotting. Red and blue arrowheads indicate 5′-tDRs likely generated by cleavage in the anticodon loops and variable loops, respectively. Asterisk indicates 5′-tDR derived from pre-tRNATyr-GTA (Akiyama et al. 2022).

This Article

  1. Published in Advance April 15, 2025, doi: 10.1261/rna.080419.125 RNA 31: 961-972

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