mRNA m6A consistency levels positively correlated with gene expression homeostasis. (A) Relative expression stability of m6A-modified genes (L, M, and H sets containing 8735, 4242, and 5279 mRNA genes, respectively) among eight different human fetal tissues. (B) Relative expression stability of m6A-modified genes (L, M, and H sets containing 12,228, 5824, and 7130 mRNA genes, respectively) among eight different adult tissues. (C) Relative expression stability of m6A-modified genes (L, M, and H sets containing 10,470, 5104, and 6842 mRNA genes, respectively) among 14 different adult tissues. (D) Relative expression stability of m6A-modified genes (L, M, and H sets containing 10,031, 4769, and 4442 mRNA genes, respectively) among eight different human cell lines. (E) Relative expression stability of m6A-modified genes (L, M, and H sets containing 12,906, 3913, and 2913 mRNA genes, respectively) among 11 different mouse tissues. (F) Relative expression stability of m6A-modified genes (L, M, and H sets containing 10,653, 4754, and 4449 mRNA genes, respectively) among six different mouse cell lines. Significance was evaluated by two-sided Mann–Whitney test.
