Comprehensive analysis of m6A-seq data reveals distinct features of conserved and unique m6A sites in mammals

Overlap analysis and protein–protein interaction network of m6A-binding proteins identified in human cell lines and three types of human tissues. (A) Overlap analysis of nine m6A-binding proteins that prefer binding to consistent m6A sites. (B) Overlap analysis of 40 m6A-binding proteins that prefer binding to unique m6A sites. (C) Experimentally determined protein-protein interactions between newly identified m6A-binding proteins (gray) and known m6A regulators (other colors). (PPI) Protein-protein interaction. (MS) Mass spectrometry.