m6A-binding proteins identified by m6A sites of eight consistency levels in eight adult tissues. (A) Three m6A-binding RBPs (red dots) that prefer binding to the most consistent m6A sites and 21 m6A-binding RBPs (blue dots) that repel these sites are identified through the most consistent m6A sites’ enrichment analysis. (B) Twenty m6A-binding RBPs (red dots) that prefer binding to unique m6A sites and eight m6A-binding RBPs (blue dots) that repel unique m6A sites are identified through unique m6A sites’ enrichment analysis. (C) Overlap analysis of m6A-binding proteins that prefer binding to consistent m6A sites. (D) Overlap analysis of m6A-binding proteins that prefer binding to unique m6A sites. (E) The affinity of 38 m6A-binding proteins to m6A sites of eight consistency levels in eight adult tissues. The thresholds: (1) odds ratio ≥ 1.2 or odds ratio ≤ 0.8; (2) relative contribution > 0.2 was used to identify RBPs with preference for m6A sites. Pearson residuals were used for showing preferential binding or avoidance.
