A dual effect of FUBP1 on SPA lncRNA maturation

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FIGURE 6.
FIGURE 6.

A dual effect of FUBP1 on SPAs’ expression. The model of FUBP1 regulating the expression of SPAs in the PWS bodies. FUBP1 is enriched in the PWS bodies via interacting with SPA1. It promotes the transcription of SPA-embedded polycistronic transcripts and regulates SPA1 splicing. This dual effect of FUBP1 ensures proper expression of SPAs in the PWS bodies, which may have potential roles in splicing regulation.

This Article

  1. Published in Advance March 27, 2025, doi: 10.1261/rna.080341.124 RNA 31: 807-821

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