TABLE 1.
Naturally occurring tRNAAla variants characterized in this study
| tRNA gene | tRNA variant | dbSNP ida | Anticodon | Codon read | AA replaced with Ala | Allele frequency (%)b | Probability of tRNA activity (%)c |
|---|---|---|---|---|---|---|---|
| Ala-AGC-6-1 | G35C | rs1041881 | ACC | GGU/C/A | Gly | 6.5 | 55.3 |
| Ala-CGC-1-1 | G35T | rs753073211 | CUC | GAG | Glu | 0.0004 | 83.9 |
| Ala-TGC-4-1 | G35A | rs953243513 | UAC | GUA/G | Val | 0.009 | 96.2 |
| Ala-AGC-8-1 | C36T | rs952897218 | AGU | ACU/C/A | Thr | 0.0008 | 97.2 |
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aSingle-nucleotide polymorphism database (dbSNP) accession identifiers are listed (Phan et al. 2025).
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bAllele frequencies are based on data from the TOPMED database (Freeze 8) (Taliun et al. 2021).
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ctRNA gene activity probability values are from Chan and Lowe (2016).
