Natural human tRNAAla anticodon variants mistranslate the genetic code

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 4.
FIGURE 4.

mCherry protein levels in normal and mistranslating cells. (A) Western blots of mCherry and a GAPDH loading control from cells transfected with plasmids bearing mCherry and the indicated wild-type or mutant tRNAAla. (B) Quantitation of mCherry protein levels normalized by GAPDH. Independent sample t-tests were computed (** P ≤ 0.001, *** P ≤ 0.001) based on at least n = 3 biological replicates.

This Article

  1. Published in Advance March 21, 2025, doi: 10.1261/rna.080450.125 RNA 31: 791-806

Current Issue

  1. July 2026, 32 (7)
  1. Current Issue
  1. Alert me to new issues of RNA