Natural human tRNAAla anticodon variants mistranslate the genetic code

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FIGURE 1.
FIGURE 1.

Schematic of tRNA-dependent Ala mistranslation. (A) Wild-type tRNAAla with anticodon NGC (3′-CGN-5′), (N = A/G/C/T) recognizes Ala codons (5′-GCN-3′). (B) Anticodon mutations to tRNAAla genes found in human genomes cause misreading of Gly (G35C) (Hasan et al. 2023), Glu (G35T), Val (G35A), and Thr (C36T) codons with Ala.

This Article

  1. Published in Advance March 21, 2025, doi: 10.1261/rna.080450.125 RNA 31: 791-806

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