ASOBIOTICS 2024: an interdisciplinary symposium on antisense-based programmable RNA antibiotics

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FIGURE 4.
FIGURE 4.

The process of antisense-mediated bacterial killing can be broken down into four stages: (i) ASO delivery to the bacteria at the site of interest in the human body; (ii) cell entry; (iii) search for and recognition of the target mRNA of interest in the bacterial cytosol; and (iv) initiation of cell death as a consequence of preventing the synthesis of an essential protein.

This Article

  1. Published in Advance January 15, 2025, doi: 10.1261/rna.080347.124 RNA 31: 465-474

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