N6-methyladenosine reader YTHDF2 in cell state transition and antitumor immunity

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FIGURE 1.
FIGURE 1.

The role of YTHDF2 in HSCs, iPSCs, AML cells, and different immune cells. (Top) The m6A/YTHDF2 influences the differentiation or proliferation of HSCs, iPSCs, and AML cells. (Bottom) YTHDF2 affects DC migration and the cross presentation of antitumoral macrophages and maintains the suppressive function of MDSCs and Tregs. In general, inhibiting YTHDF2 triggers the antitumor immunity. Figure created with BioRender.

This Article

  1. Published in Advance December 24, 2024, doi: 10.1261/rna.080259.124 RNA 31: 395-401

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