Depurination of sarcin/ricin loop 25S rRNA is signaled through the small ribosomal subunit during translation

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FIGURE 7.
FIGURE 7.

Model depicting 25S rRNA depurination leading to slow-moving ribosomes that are signaled by Mag2- and Hel2-dependent 18S NRD. The primary pathway activated in response to rRNA depurination is highlighted in pink. Other pathways, including the Gcn2-mediated ISR, Rtt101-mediated 25S NRD, Hel2-mediated RQC, and Fap1-mediated 18S NRD, did not play a major role in recognizing 25S rRNA depurination.

This Article

  1. Published in Advance September 23, 2025, doi: 10.1261/rna.080559.125 RNA 31: 1812-1825

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