From activator to suppressor: PACT is joining the company of PKR negative regulators

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FIGURE 1.
FIGURE 1.

Mechanisms of PKR suppression. (A) ADAR1 p150 (blue) uses editing-dependent and editing-independent mechanisms to prevent PKR activation. (B) PACT dimers (green) occupy dsRNA molecules and prevent PKR scanning and dimerization. In addition, PACT dsRBD2 can directly bind to the PKR kinase domain and block its activity. (C) DHX9 (brown) likely sequesters dsRNA in the nucleus preventing its detection by PKR in the cytoplasm. (D) The exoribonuclease XRN1 (yellow) likely degrades dsRNA. Created in BioRender (https://BioRender.com/ta5mgpx).

This Article

  1. Published in Advance September 3, 2025, doi: 10.1261/rna.080743.125 RNA 31: 1539-1541

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