m⁶A methylation inhibits recruitment of the Dand5 3′UTR to the left–right determinant Bicc1

AlphaFold structure modeling of Bicc1 KH2 domain binding to the RNA sequence AGACG with and without m⁶A methylation. (A) Strategy to model the complex between the KH2 domain and the AGACG motif and to evaluate the impact of m⁶A methylation. (B,C) Diagram summarizing the predicted hydrogen bonds (H-bonds) between the KH2 domain and the nucleobases of the unmodified RNA hexamer sequence (B) and its m⁶A-methylated form (C) after 5 psec of MD simulation. Asterisks (*) indicates amino acids forming H-bonds via their main chain.