Investigating the role of RNA-binding protein Ssd1 in aneuploidy tolerance through network analysis

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FIGURE 1.
FIGURE 1.

Fourteen RBPs show significant overlap in targets with Ssd1. (A) The matrix shows 280 mRNAs bound by Ssd1 (rows) and bound status (dark blue box) by each of 65 RBPs (columns). RBPs whose targets significantly overlap Ssd1 targets (FDR < 0.05) are labeled along the top. (B) A plot showing the number of mRNAs bound by each of 39 RBPs that share at least three RNA targets with Ssd1 (x-axis, see Materials and Methods) and the fraction of those targets that overlap Ssd1-bound targets (y-axis). Significant RBPs are shown in orange circles, where the size of the circle is proportionate to the enrichment P-value as indicated in the key. (C) A summary of 14 enriched RBPs and the functional processes they participate in.

This Article

  1. RNA 31: 100-112