TABLE 1.
Summary of the protein features and functions of CPSF subunits
| Subunits | Molecular masses (kDa) | Domains | Functions |
|---|---|---|---|
| CPSF160 | 160 | WD repeats | Scaffold. Coordinates AAUAAA recognition |
| CPSF100 | 88 | MβL; β-CASP | Required for cleavage |
| CPSF73 | 73 | MβL; β-CASP | Cleavage |
| CPSF30 | 30 | Zinc fingers; zinc knuckle | AAUAAA recognition |
| FIP1 | 66 | Disordered | Scaffold. CPSF assembly. Stimulates poly(A) polymerase |
| WDR33 | 146 | WD repeats; collagen-like | AAUAAA recognition |
| RBBP6 | 202 | UBL; zinc knuckle; RING finger; RS; Rb-binding; p53-binding | Activates cleavage |
| Symplekin | 135 | HEAT repeats | Scaffold. Required for cleavage |
