Principles, functions, and biological implications of m6A in plants
- Peizhe Song1,4,
- Zhihe Cai1,4 and
- Guifang Jia1,2,3
- 1Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
- 2PKU-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
- 3Beijing Advanced Center of RNA Biology, Peking University, Beijing 100871, China
- Corresponding author: guifangjia{at}pku.edu.cn
-
↵4 These authors contributed equally to this work.
Abstract
Over the past decade, N6-methyladenosine (m6A) has emerged as a prevalent and dynamically regulated modification across the transcriptome; it has been reversibly installed, removed, and interpreted by specific binding proteins, and has played crucial roles in molecular and biological processes. Within this scope, we consolidate recent advancements of m6A research in plants regarding gene expression regulation, diverse physiologic and pathogenic processes, as well as crop trial implications, to guide discussions on challenges associated with and leveraging epitranscriptome editing for crop improvement.
Keywords
- N6-methyladenosine (m6A)
- m6A effectors
- gene regulation
- physiologic and pathogenic processes
- crop improvement
This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
