Using the SEEKR P-value function to augment evolutionary studies of lncRNAs. (A,B) Distributions of SEEKR-derived r-values calculated using k = 6 for all human–mouse lncRNA pairs defined as coPARSE in human and mouse (A; HM set) and human, mouse, and zebrafish (B; HMZ) set (Huang et al. 2024). HM and HMZ r-values are binned in discrete bars, with corresponding counts shown on the right-hand y-axes. Orange bars, binned counts of lncRNA pairs whose P-values of similarity are <0.05; blue bars, all other bins. Green lines mark SEEKR-derived r-values between exemplar pairs of conserved human and mouse lncRNAs. SEEKR-derived r-values for all pairwise comparisons of human lncRNAs are shown as continuous gray distributions whose densities are displayed on the left-hand y-axes.
