Rho induction enhanced the positional correlation between Tho2 and Rrp6. (A) Colocalization of the Tho2, Hpr1, Mft1, and Rrp6 ChIP-seq peaks estimated through an EDF correlogram showing the positional correlation of each protein pair. NA stands for nonapplicable in case not enough peaks were available to calculate the correlation. (B) Venn diagram plotting the overlap of the Tho2 and Rrp6 ChIP-seq peaks. (C) The drawing depicts the possible dual role of Tho2, either as part of THO or as a factor that flags aberrant mRNPs, targeting them for degradation by Rrp6. Successfully assembled mRNP is bound by THO and exported to the cytoplasm. Conversely, aberrant mRNPs are bound by Tho2, which recruits Rrp6 that then degrades aberrant local transcripts.
