FIGURE 1.
Method overview. (A) Examples of known reactivities of sulfinate salts with nucleobase and nucleobase-like heteroarene substrates. (B) The mechanism for the formation and addition of carbon-centered radicals onto heteroarene substrates using sulfinate salts. (C) Examples of potentially sulfinate-reactive aromatic groups found within proteins and nucleic acids. Examples of reactive C–H sites are indicated with blue arrows. (D) Previously published example of successful protein labeling with sulfinate salts. (E) Our two-step DNA/RNA labeling procedure proposed in this work.
