Consequences of depleting TNRC6, AGO, and DROSHA proteins on expression of microRNAs

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FIGURE 1.
FIGURE 1.

Effect of depleting essential RNAi factors on cellular miRNA profile. (A) Canonical miRNA biogenesis and miRNA guide strand incorporation into RNA-induced silencing complex (miRISC). (B) Experimental scheme for analyzing HCT116 WT and knockout cell lines by small-RNA-sequencing (RNA-seq). (C) Global hairpin and mature reads from RNA-seq and edgeR analysis.

This Article

  1. Published in Advance May 11, 2023, doi: 10.1261/rna.079647.123 RNA 29: 1166-1184

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