Translation regulation by a guanidine-II riboswitch is highly tunable in sensitivity, dynamic range, and apparent cooperativity

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FIGURE 7.
FIGURE 7.

(A) Secondary structure highlighting the two GU wobbles in the P1 and P2 stems. (B) Representative SMARTI response profiles of the four single mutations restoring Watson–Crick pairing in the P1 and P2 wobbles. (C) Gel-based RelE cleavage curves for the G13A (n = 3), U26C (n = 2), G13A;G46A (n = 3), and U26C;U57C (n = 3) mutants.

This Article

  1. Published in Advance May 2, 2023, doi: 10.1261/rna.079560.122 RNA 29: 1126-1139

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