Overview of the Cm B complex homology model (PDB 5O9Z). All protein sequences were annotated by conservation with their Cm homologs. Identical and similar amino acids are colored purple while dissimilar amino acids are colored wheat. Right insets show regions of high conservation, which are also positions of helices formed by U2 snRNA and the BPS (upper right), as well as U6 snRNA and the 5′ splice site (lower right). (Left inset) Surface representation of Prp38 and associated proteins in the Cm B complex (PDB 5O9Z). Cm Prp38 lacks Prp38 complex-associated proteins FBP21, Spp381 and Snu23. Proteins absent in Cm are shown in transparent gray. The RNA is colored as follows: U6 (dark red); U4 (yellow); U5 (green); U2 (blue); and pre-mRNA (cyan).
