Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes

Surface representation of the Cm B complex homology modeled against the human structure (PDB 5O9Z). All protein sequences were annotated by conservation with their Cm homologs. Identical and similar amino acids are colored purple while dissimilar amino acids are colored wheat. Proteins absent in Cm are shown in transparent gray. The RNA is colored as follows: U6 (dark red); U4 (yellow); U5 (green); U2 (blue); and pre-mRNA (cyan).