FIGURE 5.
Surface representation of the Cm U4/U6.U5 tri-snRNP homology modeled against the human structure (PDB 3JCR). All protein sequences were annotated by conservation with their Cm homologs. Identical and similar amino acids are colored purple while dissimilar amino acids are colored wheat. Proteins absent in Cm are shown in transparent gray. The RNA is colored as follows: U6 (dark red); U4 (yellow); and U5 (green). (Inset) Surface representation of the amino- and carboxy-terminal cassettes of Cm Brr2 homology modeled against the human structure (PDB 3JCR). The amino-terminal plug domain of Brr2 that is absent in Cm is shown in magenta.
