Surface representation of the Cm P complex homology modeled against the Sc structure (PDB 5YLZ). All protein sequences were annotated by conservation with their Cm homologs. Identical and similar amino acids are colored purple while dissimilar amino acids are colored wheat. (Inset) the intron lariat junction from the Sc P complex active site (PDB 5YLZ). The 1585 loop (present in CmPrp8) and Toggle loop (missing in CmPrp8) are represented in cartoon, while the respective linker and RNase H domains of CmPrp8 are represented as surfaces. Proteins absent in Cm are shown in transparent gray. The RNA is colored as follows: U6 (dark red); U5 (green); U2 (blue); and pre-mRNA (cyan).
