FIGURE 10.
Surface representation of the Cm C* complex homology modeled against the human structure (PDB 5MQF). All protein sequences were annotated by conservation with their Cm homologs. Identical and similar amino acids are colored purple while dissimilar amino acids are colored wheat. (Inset) Several proteins are missing or are poorly conserved within the Cm 3′SS/BPS region, highlighting the importance of CmPrp8 in the second transesterification. Proteins that are absent in Cm are shown in transparent gray. The RNA is colored as follows: U6 (dark red); U5 (green); U2 (blue); and pre-mRNA (cyan).
