Phase-separated ribosome-nascent chain complexes in genotoxic stress response

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FIGURE 6.
FIGURE 6.

Phase separation is involved in DNA damage response. (A) 700–700 A549 cells were plated and treated or not with HEX in 0.5% v/v and exposed or not to 1 Gray (1 Gy) or two times 1 Gy irradiation dose with a 30 min incubation time between the two treatments (2 Gy). (B) Chart showing the combined results of the experiment described in A with three independent biological replicates. Survivals are expressed in % of survivals of nonirradiated plates. Statistical significance in the case of comparing 2 Gy to 2 Gy + HEX is determined by a two-tailed Student's t-test ([*] P < 0.05).

This Article

  1. RNA 29: 1557-1574