Small-molecule Ro-08-2750 interacts with many RNA-binding proteins and elicits MUSASHI2-independent phenotypes

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 3.
FIGURE 3.

Ro interacts with multiple RRM containing RBPs. (A) Depiction of PISA assay. (B) Volcano plot of the change in relative temperature-dependent solubility of measured proteins with respect to Ro treatment compared with significance (−log10 P-value). (C) Top 15 gene ontology molecular functions enriched in proteins identified as Ro interactors from PISA assay. (D) Bar plot showing the count of each RBD domain type for RBPs enriched as PISA interactors.

This Article

  1. Published in Advance June 27, 2023, doi: 10.1261/rna.079605.123 RNA 29: 1458-1470

Current Issue

  1. July 2026, 32 (7)
  1. Current Issue
  1. Alert me to new issues of RNA