Cover image

Dicer-related helicase 3 (DRH-3) C-terminal domain with dsRNA (PDB id: 6M6R; Li K, Zheng J, Wirawan M, Trinh NM, Fedorova O, Griffin PR, Pyle AM, Luo D. 2021. Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 [DRH-3]. Nucleic Acids Res 49: 9978–9991). C. elegans dicer-related helicase 3 (DRH-3) is critically involved in germline development and RNA interference (RNAi) facilitated chromosome segregation. The C-terminal domain preferentially recognizes 5′-triphosphorylated double-stranded RNAs bearing the typical features of secondary siRNA transcripts. RNA backbone is displayed as a red ribbon; block bases use NDB colors: C—yellow, G—green; protein is displayed as a gold ribbon. Cover image provided by the Nucleic Acid Database (ndbserver.rutgers.edu). Image generated using DSSR and PyMOL (Lu XJ. 2020. Nucleic Acids Res 48: e74).