FIGURE 1.
The TFB1M–rRNA crystal structure suggests how other members of the rRNA adenine dimethylase family of proteins may bind substrate RNA. (A) A phylogram of rRNA adenine dimethylase (RRAD) family proteins from model organisms. (B) A schematic for the methylation reaction performed by two RRAD family members, ErmE, and TFB1M, is shown. Both proteins dimethylate an adenosine residue adjacent to a base-paired stem region. (C) The crystal structure of TFB1M bound to substrate was recently solved, revealing details of its interactions with rRNA.
