Cover image

Human adenosine deaminase (E488Q mutant) acting on dsRNA (PDB id: 6VFF; Thuy-Boun AS, Thomas JM, Grajo HL, Palumbo CM, Park S, Nguyen LT, Fisher AJ, Beal PA. 2020. Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. Nucleic Acids Res. https://doi.org/10.1093/nar/gkaa532). Adenosine deaminase enzymes convert adenosine to inosine in duplex RNA, a modification that strongly affects RNA structure and function in multiple ways. The dsRNA backbone is displayed as a red ribbon; block bases use NDB colors: A—red, C—yellow, G—green, U—cyan; displaced 8-aza-nebularine (a derivative) base is shown in bright magenta. Protein is displayed as a white ribbon; the protein side chain of mutated residue E448Q is highlighted in dark magenta. Cover image provided by the Nucleic Acid Database (ndbserver.rutgers.edu). Image generated using DSSR and PyMOL (Lu XJ. 2020. Nucleic Acids Res 48: e74).