Cover image

Mutant editing enzyme in complex with dsRNA (PDB id: 6d06; Monteleone LR, Matthews MM, Palumbo CM, Thomas JM, Zheng Y, Chiang Y, Fisher AJ, Beal PA. 2019. A bump-hole approach for directed RNA editing. Cell Chem Biol 26: 269). Human ADAR2 (adenosine deaminase acting on RNA 2) with mutation E448Y has reduced background RNA editing. RNA is displayed as a red ribbon; block bases use NDB colors: A—red, C—yellow, G—green, U—cyan; enzyme is displayed as a gold ribbon. Enzyme cofactor inositol hexakisphosphate is shown as spheres. The image was generated using 3DNA/blocview and PyMol software. Cover image provided by the Nucleic Acid Database (ndbserver.rutgers.edu).