Cover image

Rhodobacter sphaeroides Argonaute with guide RNA/target DNA duplex containing noncanonical A-G pair (Protein Data Bank code: 6d9k; Liu Y, Esyunina D, Olovnikov I, Teplova M, Kulbachinskiy A, Aravin AA, Patel DJ. 2018. Accommodation of helical imperfections in Rhodobacter sphaeroides Argonaute ternary complexes with guide RNA and target DNA. Cell Rep 24: 453–462). Guide RNA backbone is displayed as a red ribbon; target DNA backbone is displayed as an orange ribbon; bases are shown as blocks with NDB coloring: A—red, C—yellow, G—green, U—cyan, T—blue; Argonaute protein is displayed as a silver ribbon. The image was generated using 3DNA/blocview and PyMol software. Cover image provided by the Nucleic Acid Database (ndbserver.rutgers.edu)