Cover image

Crystal structure of human Argonaute-1 (hAgo1) in complex with let-7 guide RNA (Protein Data Bank code: 4krf; Faehnle CR, Elkayam E, Haase AD, Hannon GJ, Joshua-Tor L. 2013. The making of a slicer: Activation of human Argonaute-1. Cell Rep 3: 1901–1909). Image details show protein—cartoon representation, blue; RNA—ribbon-plate representation, green; only nucleotides 1–10 and 21–22 are shown; for nucleotides 11–19, weak electron density is observed. The image was generated with PyMOL (DeLano Scientific LLC). Cover image provided by the Jena Library of Biological Macromolecules—JenaLib (jenalib.fli-leibniz.de).