Biogenesis of telomerase ribonucleoproteins

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FIGURE 2.
FIGURE 2.

T. thermophila telomerase RNP biogenesis. T. thermophila TER is transcribed by RNA polymerase III. The binding of p65 stabilizes a kink in stem IV that optimally positions loop IV for TERT binding. The p65-TER–TERT ternary complex then interacts with a complex of p75, p50, p45, and p19 that recruits the single-stranded telomeric DNA-binding protein Teb1.

This Article

  1. Published in Advance August 8, 2012, doi: 10.1261/rna.034629.112 RNA 18: 1747-1759

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