miTALOS: Analyzing the tissue-specific regulation of signaling pathways by human and mouse microRNAs

Proximity vs. enrichment in signaling pathways. Density of the number of targets in miRNA-pathway associations (solid line). Although the number of targets in a significantly enriched (FDR < 0.01) pathway is mainly between 10 and 20 (dotted line), significantly proximal (FDR < 0.01) targeted pathways have three to seven targets (dashed line). Thus proximity and enrichment score identify two alternative forms of miRNA control.