Mechanistic insights from reversible splicing catalysis

  1. Duncan J. Smith and
  2. Maria M. Konarska
  1. The Rockefeller University, New York, New York 10021, USA

Abstract

Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.

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Footnotes

  • Reprint requests to: Duncan J. Smith, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA; e-mail: dsmith{at}mail.rockefeller.edu; or Maria M. Konarska, The Rockefeller University, New York, NY 10021, USA; e-mail: konarsk{at}mail.rockefeller.edu.

  • Article published online ahead of print. Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.1289808.

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  1. Published in Advance August 28, 2008, doi: 10.1261/rna.1289808 RNA 14: 1975-1978 Copyright © 2008 RNA Society

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