N6-methyladenosine reader YTHDF2 in cell state transition and antitumor immunity
- 1 Institute of Microbiology, Chinese Academy of Sciences;
- 2 Department of Radiation and Cellular Oncology, University of Chicago;
- 3 The University of Chicago Chicago
- ↵* Corresponding author; email: chuanhe{at}uchicago.edu
Abstract
Recent studies revealed that the YTHDF family proteins bind preferentially to the N6-methyladenosine (m6A)-modified mRNA and regulate functions of these RNAs in different cell types. YTHDF2, the first identified m6A reader in mammals, has garnered significant attention because of its profound effect to regulate the m6A epitranscriptome in multiple biological processes. Here, we review current knowledge on the mechanisms by which YTHDF2 exerts its functions and discuss recent advances that underscore the multifaceted role of YTHDF2 in development, stem cell expansion and immune evasion. We also highlight potential therapeutic interventions targeting the m6A/YTHDF2 axis to improve the response to current antitumor therapies.
- Received September 12, 2024.
- Accepted December 16, 2024.
- Published by Cold Spring Harbor Laboratory Press for the RNA Society
This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
