The je ne sais quoi of 5-methylcytosine in messenger RNA
- 1 Australian National University, John Curtin School of Medical Research;
- 2 The John Curtin School of Medical Research
- ↵* Corresponding author; email: thomas.preiss{at}anu.edu.au
Abstract
The potential presence of 5-methylcytosine as a sparse internal modification of mRNA was first raised in 1975 and a first map of the modification was also part of the epitranscriptomics ‘big bang’ in 2012. Since then, the evidence for its presence in mRNA has firmed up and initial insights have been gained into the molecular function and broader biological relevance of 5-methylcytosine when present in mRNA. Here, we summarise the status quo of the field, outline some of its current challenges and suggest how to address them in future work.
Keywords
- Received February 4, 2024.
- Accepted February 9, 2024.
- Published by Cold Spring Harbor Laboratory Press for the RNA Society
This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
