The Multi-structural Forms of Box C/D Ribonucleoprotein Particles
- ↵* Corresponding author; email: hong.li{at}fsu.edu
Abstract
Structural biology studies of archaeal and yeast box C/D ribonucleoprotein particles (RNPs) reveal a surprisingly wide range of forms. If form ever follows function, the different structures of box C/D small ribonucleoprotein particles (snoRNPs) may reflect their versatile functional roles beyond what have been recognized. A large majority of box C/D RNPs serve to site-specifically 2’-hydroxyl methylate the ribosomal RNA, typically as independent complexes, Select members of the box C/D snoRNPs also are essential components of the megadalton RNP enzyme, the small subunit processome, responsible for processing ribosomal RNA. Other box C/D RNPs continue to be uncovered with either unexpected or unknown functions. We summarize currently known box C/D RNP structures in this review and identify the Nop56/58 and the box C/D RNA subunits as the key elements underlying the observed structural diversity, and likely, the diverse functional roles of box C/D RNPs.
Keywords
- Received August 5, 2018.
- Accepted September 22, 2018.
- Published by Cold Spring Harbor Laboratory Press for the RNA Society
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