A family of poly(U) polymerases
Abstract
The GLD-2 family of poly(A) polymerases add successive AMP monomers to the 3′ end of specific RNAs, forming a poly(A) tail. Here, we identify a new group of GLD-2-related nucleotidyl transferases from Arabidopsis, Schizosaccharomyces pombe, Caenorhabditis elegans, and humans. Like GLD-2, these enzymes are template independent and add nucleotides to the 3′ end of an RNA substrate. However, these new enzymes, which we refer to as poly(U) polymerases, add poly(U) rather than poly(A) to their RNA substrates.
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Footnotes
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Reprint requests to: Marvin Wickens, Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, WI 53706, USA; e-mail: wickens{at}biochem.wisc.edu; fax: (608) 262-9108.
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Article published online ahead of print. Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.514007.
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- Received February 16, 2007.
- Accepted March 1, 2007.
- Copyright © 2007 RNA Society
