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Cover Illustration: Solution structure of an RNA duplex with tandem GA mismatches (Protein Data Bank code: 1mis; ribbon/sticks representation; coloring scheme: A, red; U, magenta; G, green; C, blue).The image was generated with InsightII from Accelrys,Inc. Cover image provided by IMB Jena Image Library of Biological Macromolecules (www.imb-jena.de/IMAGE.html).