FIGURE 5.
Model of editing and splicing of GluR-B pre-mRNA in vitro and in vivo. (A) ADAR2 (black circle) competes with splicing factors (SF, gray circle) for binding to the R/G stem-loop in vitro. Disruption of the stem-loop by RNA helicase A (RHA, checked oval) facilitates the binding of splicing factors and thereby enhances splicing. (B) In vivo, editing and splicing is coordinated, possibly by the CTD (black rectangle) of RNA pol II. RHA might be the link between RNA processing factors and the polymerase. Editing (1.) and splicing (2.) are sequential events occurring in vivo.
