Inhibition of Escherichia coli RNase P by oligonucleotide directed misfolding of RNA

Inhibition of processing of B. subtilis pre-tRNA^Asp via ODMiR during transcription of E. coli RNase P RNA. (A) Autoradiogram of a gel for transcriptions in the presence or absence of m(CAGCCUACCCGG) with RNase P protein (left) and an autoradiogram of a gel for transcriptions in the presence or absence of m(CAGCCUACCCGG) without RNase P protein (right). (B) Plot of the percentage of pre-tRNA (open circles) and processed tRNA (filled circles) as a function of [m(CAGCCUACCCGG)]. All points have error bars, although in some instances they are smaller than the data points.